Luther Dickinson was born in western Tennessee to parents Mary Dickinson and famed Memphis producer and musician Jim Dickinson. The family moved to the north Mississippi hill country in 1985, where Luther and his brother Cody grew up going to Jr Kimbrough's juke joint and Otha Turner's fife-n-drum goat BBQ picnics.

He and his brother, Cody, started the North Mississippi Allstars in 1996 playing Hill Country Blues inspired "Mississippi RocknRoll." RL Burnside hired him to go on the road in 1997 and he has since toured all over the world from Russia to Japan to Australia.

Luther made his recording debut at age 14. He went on to record with the Replacements, Mojo Nixon, Beck, Toy Caldwell, Billy Lee Riley, Lucero, John Hiatt, Mavis Staples, Jon Spencer, Ry Cooder, Lucinda Williams, Spooner Oldham, Levon Helm, the Dirty Dozen Brass Band, George Porter, and a host of others. In the mid 1990s, Luther produced Otha Turner's albums Senegal to Senatobia and Everybody Hollerin' Goat (named one of the top ten blues records of the 90s by Rolling Stone).

Luther began recording and touring with The Black Crowes in 2007 until they went on hiatus in 2011.

In 2011, as a member of the Americana Music Award house band Luther backed up Robert Plant, Patty Griffin, Gregg Allman, Amos Lee, Justin Townes Earle and many others.

As a member of the North Mississippi Allstars, South Memphis String Band and The Word, Luther has made himself widely known as both a talented musician and as a producer with four Grammy nominations to prove it- three in the contemporary blues catagory and one in traditional folk.