As a member of Punch Brothers since the band's inception, guitarist Chris Eldridge has been at the vanguard of acoustic music for over a decade. Although initially drawn to the electric guitar, by his mid-teens Chris Eldridge had developed a deep love for acoustic music, thanks in part to his father, Ben, a banjo player and founding member of the seminal bluegrass group The Seldom Scene. Eldridge later gained in-depth exposure to a variety of different musical styles while studying at Oberlin Conservatory, where he earned a degree in music performance in 2004. During his time at Oberlin, Eldridge studied with legendary guitarist Tony Rice.

After graduating he joined the Seldom Scene with whom he received a Grammy nomination in 2007. In 2005 he founded the critically acclaimed bluegrass band The Infamous Stringdusters. At the 2007 International Bluegrass Music Association awards Eldridge and his Stringdusters bandmates won Emerging artist of the Year, Song of the Year, and Album of the Year for their debut album, Fork in the Road.

Meanwhile, in 2005 he had caught the attention of mandolinist Chris Thile, who enlisted him, along with banjoist Noam Pikelny, violinist Gabe Witcher, bassist Greg Garrison (and later, bassist Paul Kowert) to start working on an ambitious side project. Soon after they decided to focus all of their collective energies into band and Punch Brothers was born. The band has since released 6 critically acclaimed albums, won a Grammy for Best Folk Album in 2018 and toured the world.

Eldridge also plays in a duo with guitarist Julian Lage. They have released 2 full length records and an EP. Their most recent, Mount Royal, was nominated for a Grammy for Best Contemporary Instrumental Album in 2017.

Eldridge is currently the house guitarist on the public radio show, Live From Here, formerly known as A Prairie Home Companion. In 2019, he was named Instrumentalist of the Year by the Americana Music Association.

Chris Eldridge has worked with a diverse cast of musical luminaries including Paul Simon, Renée Fleming, John Paul Jones, Marcus Mumford, Justin Timberlake, T-Bone Burnett, Jon Brion, Fiona Apple, Elvis Costello, Jerry Douglas, Sara Watkins, and Del McCoury.