Eddie Santiago (born August 18, 1955) is a salsa singer from Puerto Rico. At a young age, Eddie demonstrated great love and talent for salsa music. He performed with several groups, including Generación 2000, Orquesta La Potente, Orquesta Opus, and the Orquesta Saragüey.

Santiago's career took off in 1986 in Puerto Rico and Latin America as a soloist, formimg his own band, and recording songs including: "Tú me quemas" (You Burn Me), "Qué Locura Enamorarme de Ti" (What Madness To Fall in Love With You), "Me Fallaste" (You Failed Me), Antidoto y Veneno (Antidote and Venom), "Tu Me Haces Falta" (I Need You) and his best known hit "Lluvia" (Rain, not to be confused with Menudo's hit of the same name), and many others with his fame eventually spreading to Europe and the United States making him one of the most popular Salsa singer in the late 80's and early 90's. He was one of the main singers singing what was called "Salsa Romantica", romantic salsa, due to the romanticism present in the lyrics.

His first major recording on an international label was with Sony Music in 1999. He also recorded for the TH, EMI Latin, and Polygram labels, including the well regarded production inspired by the music of Rafael Hernández, entitled "Enamorado".