Gnarls Barkley is the collaboration between producer DJ Danger Mouse and Goodie Mob rapper/ singer Cee-Lo. Their first single, Crazy, which debuted at #1 on the British pop charts on April 2, 2006, is the first #1 UK single to be obtained solely through Internet downloads. The success of the single in the UK was due largely to its use in a promotional trailer for Radio 1 across all of the BBC TV channels prior to the single's release. 'Crazy' stayed at #1 for almost 9 weeks.

The buzz for "Crazy" helped generate a lot of press coverage of their debut album, St. Elsewhere, which was released on May 9, 2006.

The album is seen as a cross-over between hip-hop, rock and soul. Both artists have previously been known to have a quirky experimental side, moving between different genres of music.

Producer DJ Danger Mouse began his career doing remixes of indie rock artists like Neutral Milk Hotel and downbeat instrumental music under the 'Pelican City' alias. He later went on to emphasize more hip-hop production: most notably his The Grey Album, a remix of Black Album, with samples exclusively from The White Album; 2005's DangerDoom collaboration with MF DOOM; and, most recently, the double platinum Demon Days.

Gnarls Barkley singer Cee-Lo started out in the classic southern rap group Goodie Mob, but later developed a unique funk-inspired soulful style of singing which developed on his solo albums.

Their new album The Odd Couple was released March 18, 2008.