Wayne Hussey (born Jerry Wayne Hussey on 26 May 1958 in Bristol, England) is a British musician, best known as a member of The Mission and The Sisters of Mercy.

Growing up in Bristol, his early influences included Marc Bolan and his band, T. Rex. He was thus inspired to become a guitarist. Brought up in strict Mormon religion, he rebelled against his parents and moved to Liverpool in the late 1970s to join the scene around Eric's, a noted nightclub of the time.

Hussey started to perform, most notably with Pauline Murray & The Invisible Girls and getting his teeth into songwriting. The first success for Hussey came when he joined Dead or Alive at the request of frontman Pete Burns. After Burns retreated to become more studio-based Hussey decided to leave and was offered a position with the legendary The Sisters of Mercy, concentrating on 12-string and 6-string guitars. With the falling apart of the Sisters, Hussey and bassist Craig Adams set up the Mission, recruiting Mick Brown on drums and Simon Hinkler on guitars.

Hussey has produced and played on records by stablemates All About Eve and in the late 1990s provided some re-mixes for the LA based Cleopatra Records. He also produced and played on Brilliant Mistakes by the Greek band Flowers of Romance. He has played live with both Gary Numan and The Cure.

He currently lives in Brazil and is a life-long Liverpool FC supporter.