Don Dixon was born on December 13, 1950 in Lancaster, South Carolina. His college roommate was the writer Bruce Brooks.

Dixon is considered to be one of the key producers of what is called the jangle pop movement of the early 1980s. He spent thirteen years as a member of NC cult heroes Arrogance. Around 1983, Dixon attracted attention by co-producing with Mitch Easter, R.E.M.'s landmark debut LP Murmur. He then spent several years producing the work of varied artists including Chris Stamey (formerly of The dB's) and The Smithereens. Considered to be a highlight of this period was Tommy Keene's Run Now EP. This success led to Dixon recording his solo debut Most of the Girls Like to Dance But Only Some of the Boys Like To, a further affirmation of his love of classic pop melodies and spiky, Nick Lowe-inspired wordplay.

Dixon is married to the singer Marti Jones.

In 2006, Dixon released his first new album in six years, The Entire Combustible World in One Small Room.

Currently Dixon is producing the follow up album for Babyshaker. The Charlotte based hard rock glam band is recording their sophmore effort at the legendary Milestone Club, in Charlotte N.C.