Wolfgang Muthspiel (born March 2, 1965 in Judenburg, Austria) is an Austrian guitarist and composer most associated with jazz and brother of the trombonist and pianist Christian Muthspiel.

He started playing the violin at six and began study of the guitar as a teenager. After studying classical and jazz guitar in Graz, he completed his studies at the New England Conservatory and the Berklee College of Music. His high reputation, even in young years, made him the replacement of Pat Metheny in Gary Burton's band.

In the following years Muthspiel played with several famous jazz greats like Maria Joao, Dave Liebman, Peter Erskine, Paul Motian, Bob Berg, Gary Peacock, Don Alias, Larry Grenadier or John Patitucci. Later a collaboration with famous Norwegian jazz singer Rebekka Bakken followed.

In 2002 Muthspiel returned to Vienna, founding his record label Material Records, which focuses on publishing own records as well as those of young aspiring musicians.

In 2003 he won the European Jazz Prize.