Sugizo has released a multitude of solo work since 1997, including the albums Truth?, C:LEAR, Soundtrack, Silent Voice ~Acoustic Songs of Soundtrack~ and the elusive H.ART CHAOS, as well as compliation and remix albums. Sugizo has worked with artists such as 謝霆鋒, 徐若瑄 and bice as well as starring in the film Soundtrack. He is known for his anti-war sentiments and progressive sound.

Sugizo is best-known as lead guitarist and at times-violinist of LUNA SEA. Recently, he played a major part in The Flare, who have since split. Sugizo's name should be capitalised when referring to solo releases.

This year YOSHIKI and Gackt announced, that Sugizo will be the lead guitarist in so-called superband, a.k.a S.K.I.N. along with Miyavi.